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Continuous Manufacturing Modular API Plant

Corden Pharma Chenove SAS has commissioned a continuously operating modular API and intermediates synthesis plant that they recently put into operation to realize the benefits of process intensification. It consists of two feed modules with two dosing lines each, and four dosing lines altogether. Two of those dosing lines are made of Hastelloy, one is… Continue Reading →

80 Flow Chemistries and Flow Processes, Part 1: Polymers

Based on nearly 20 years in the field of flow process design the team at Microinnova has executed more than 200 projects in flow chemistry. Different types of polymerization reactions have been executed including free-radical and ionic polymerizations, as well as polyester and oligomer synthesis. We address product quality and safety issues since these types… Continue Reading →

Microinnova Strengthens the Field of Digital Processing…

…by kicking off the Project “PharmComplete” using Digital Twin, Model-Predictive-Control and PAT strategies. A shift towards more efficient and controlled processes is taking place in the pharmaceutical industry with process analytical technologies, continuous manufacturing and advanced process control strategies being central elements. While different suppliers make plug and play lines available, especially in the field… Continue Reading →

Microinnova Sponsors Award for Outstanding Process Intensification Work Towards CO2 Reduction

We were honored to have the opportunity to sponsor the 2021 EFCE Excellence Award in Process Intensification! The recipient of this award was Dr. Evangelos Delikonstantis whose Ph.D. work, titled “Plasma-Assisted Non-Oxidative Methane Coupling to Olefins”, looked into how methane can be converted to ethylene using a nanosecond pulsed plasma. Dr. Kirschneck, who presented the… Continue Reading →

Intensification Boost for Enzymatic Liquid/Gas Processes by Means of Continuous Flow Processing

BACKGROUND O2-dependent biotransformation reactions have proven difficult in fine chemical manufacturing due to the mass transfer limitations of supplying O2 to the enzymatic reaction, hence affecting the level of efficiency achieved. Previous research has shown that enzymatic processes involving gases have a high potential for process intensification by implementing continuous flow processing technology. TECHNOLOGY In… Continue Reading →


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