Microinnova has delivered two modular continuous crystallization plants to the CMAC Research Centre in Scotland and one crystallization plant with an integrated filter-dryer unit to the University of Sheffield. These systems address the complexities of continuous crystallization, filtration, and drying – key challenges in downstream processing for API manufacturing.
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Designed for pilot-scale research, these plants feature a high level of automation and flexibility, enabling quick reconfiguration to support various crystallization processes. By combining process and development data on a unified platform, researchers can efficiently develop and optimize continuous crystallization techniques. The use of highly resistant materials ensures broad applicability across different substances, while online analytics and Process Analytical Technology (PAT) tools provide real-time monitoring and Model Predictive Control (MPC).
The plants are equipped for advanced Model Predictive Control (MPC), with capabilities for integrating PAT tools like Focused Beam Reflectance Measurement (FBRM) and Real-Time Microscopy (RTM). This integration allows for precise process control and optimization. With a processing capacity of 1 to 8 liters per hour, these modular systems deliver the versatility needed for developing efficient and reliable crystallization processes for pharmaceutical intermediates and APIs.
Microinnova’s continuous crystallization solutions support cutting-edge research, providing the tools necessary to enhance efficiency, flexibility, and quality in pharmaceutical manufacturing.